The cerebral perivascular cells

Cover of: The cerebral perivascular cells |

Published by Springer in Berlin, New York .

Written in English

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  • Antigen presenting cells.,
  • Brain -- Immunology.,
  • Rodents -- Immunology.

Edition Notes

Includes bibliographical references (p. 77-87) and index.

Book details

StatementD.N. Angelov ... [et. al.].
SeriesAdvances in anatomy, embryology, and cell biology ;, v. 147
ContributionsAngelov, D. N. 1953-
LC ClassificationsQL801 .E67 vol. 147, QR185.8.A59 .E67 vol. 147
The Physical Object
Paginationxi, 90 p. :
Number of Pages90
ID Numbers
Open LibraryOL365558M
ISBN 103540646388
LC Control Number98025894

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The cerebral perivascular cells. [D N Angelov;] Presentation and Antigen Presenting Cells.- Antigen Presentation within the CNS.- Microglia Might Be the Cerebral Antigen Presenting Cells.- Theories on the Antigen Presentation Site.- Questions Still Open.- Methodological Approach.- 2 Materials and Methods.- Animals.

The Cerebral Perivascular Cells (Advances in Anatomy, Embryology and Cell Biology) Softcover reprint of the original 1st ed. Edition by D. Angelov (Author) ISBN ISBN Why is ISBN important. ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book.

Cited by: The Cerebral Perivascular Cells book. Read reviews from world’s largest community for :   The Cerebral Perivascular Cells. by Doychin N. Angelov,Michael Walther,Michael Streppel,Orlando Guntinas-Lichius,Wolfram F.

Neiss. Advances in Anatomy, Embryology and Cell Biology (Book ) Thanks for Sharing. You submitted the following rating and review. We'll publish them on our site once we've reviewed : Springer Berlin Heidelberg. The Cerebral Perivascular Cells.

Authors (view affiliations) D. Angelov this monograph summarizes results from voluminous work to establish which indigenous cerebral cells might present (auto)antigen to the immune system and thus initiate an (auto)immune reaction. that the only cells in the rat CNS which can be regarded as the.

Get this from a library. The cerebral perivascular cells. [D N Angelov;] -- Following an exhaustive literature review on the global issue of intracerebral presentation of antigen, this monograph summarizes results from voluminous work to establish which indigenous cerebral.

The foamy cells that appeared along the cerebral microvessels in lipidosis and saccharidosis were identified as perivascular macrophages (Mato's fluorescent granular perithelial cells: FGP cells. Although the perivascular cells are in the vicinity of the basal lamina of the cerebral vasculature, they must not be confused with the pericytes, which are not able to perform phagocytosis.

In contrast, the perivascular cells are macrophages-ED2 recognizes an Cited by: The cerebral perivascular cells book ability to selectively manipulate perivascular cells holds promise for further informing mechanisms of immune-to-brain, and for intervening in pathologies that may result from dysfunction of.

True cerebral vasculitis, not just perivascular cuffing, is rarely demonstrated. Microglial cells are resident macrophages in the brain and are of mesodermal, not ectodermal, origin.

Increased numbers of immunoreactive microglial cells occur in a variety of conditions, including ischemic infarction of brain, encephalitis, vasculitis, and in. Ronald F Tuma, in Microcirculation, Endothelial Control.

As described previously, endothelial The cerebral perivascular cells book in the cerebral microcirculation are a key component of the BBB, helping to protect the brain interstitial fluid from shifts in ionic concentration, and chemicals that could adversely influence neuronal function.

A perivascular space, also known as a Virchow–Robin space, is a fluid-filled space surrounding certain blood vessels in several organs, including brain, potentially having an immunological function, but more broadly a dispersive role for neural and blood-derived messengers.

The brain pia mater is reflected from the surface of the brain onto the surface of blood vessels in the subarachnoid space. Meningeal and Perivascular Macrophages of the Central Nervous System Play a Protective Role During Bacterial Meningitis Article (PDF Available) in The Journal of Immunology (8) The perivascular FGP (Mato) cells are capable of uptaking excessive fluid in the vascular wall caused by hyperpermeability of cerebral microvessels.

In experiments 1 and 2, in accordance with the increase of pinocytosis in endothelium, the FGP cells became rich in vesicles and vacuoles; they demonstrated deep plasmalemmal infoldings and were Author: Masao Mato.

In the past few decades, knowledge of the nerve supply to the major cerebral arteries in various animals has increased markedly. The perivascular nerves have been classified as sympathetic, parasympathetic, and sensory, with each group being characterized by particular neurotransmitters (Edvinsson et al., a).The functions of cerebrovascular nerves, however, have not yet been Cited by:   T1 - The Glymphatic System and Brain Interstitial Fluid Homeostasis.

AU - Iliff, Jeffrey. AU - Thrane, A. AU - Nedergaard, M. PY - /3/7. Y1 - /3/7. N2 - This chapter reviews the basis of brain interstitial fluid homeostasis and discusses the roles of the glymphatic system in the clearance of fluid and by: 2.

Cerebral autoregulation is the ability of the cerebral vasculature to maintain stable blood flow despite changes in blood pressure (or, more accurately, cerebral perfusion pressure). [1] Under normal circumstances, cerebral blood flow is regulated through changes in arteriolar diameter, which, in turn, drive changes in cerebrovascular resistance following the Hagen-Poiseuille equation.

[2]Author: Andrew Silverman, Nils H. Petersen. Microglia are a type of neuroglia (glial cell) located throughout the brain and spinal cord. Microglia account for 10–15% of all cells found within the brain. As the resident macrophage cells, they act as the first and main form of active immune defense in the central nervous system (CNS).

Microglia (and other neuroglia including astrocytes) are distributed in large non-overlapping regions. Periventricular leukomalacia (PVL) is a form of white-matter brain injury, characterized by the necrosis (more often coagulation) of white matter near the lateral ventricles.

It can affect newborns and (less commonly) fetuses; premature infants are at the greatest risk of neonatal encephalopathy which may lead to this condition. Affected individuals generally exhibit motor control problems or Specialty: Pediatrics.

This chapter examines the relation between the blood–brain barrier (BBB) and perivascular cells. It explains that the BBB is a dynamic interface between blood and brain which restricts the entry of plasma constituents that could interfere negatively with brain function while allowing substances which are essential for brain metabolism and function to enter the brain.

F1: Figure 1. Crossing of the blood-brain barrier (BBB) by parasites associated with WBCs. (A) Illustration of a cerebral post-capillary vessel showing the BBB, consisting of a complex of cerebral endothelial cells and their tight junctions, basement membranes and pericytes as.

One of the most challenging aspects of treating disorders of the central nervous system (CNS) is the efficient delivery of drugs to their targets within the brain. Only a small fraction of drugs is able to cross the blood–brain barrier (BBB) under physiological conditions, and this observation has prompted investigation into the routes of administration that may potentially bypass the Cited by: 2.

The fact that none of these parameters was recorded during the experiments is a major drawback, since each of the parameters may alter cerebral blood flow, cerebral blood volume, intracranial pressure and even the perivascular pump. Each of these parameters may in turn influence ISF and CSF circulation and the width of the interstitial space.

In addition to forming tight junctions, cerebral endothelial cells express a number of key drug transporters at the luminal plasma membrane that restrict the transendothelial passage of many drugs from the blood into the CNS [5,6].

Molecules able to cross the BBB under physiological conditions are typically small (Cited by: 2. Human Post-Mortem Brain Tissue.

We analyzed sections of prefrontal cortex from neurotypical human post-mortem brain tissue stained for Nissl (n = 5 cases MD, MD, VA, MD, and MD) and for the electron microscope (n = 5 cases MD, B, B, B, B).

We studied neurons and glial cell types in ar Cited by: The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular existence of such a physical, enzymatic, and active barrier isolating the central nervous system has.

Cholinergic receptors have been located on endothelial cells, smooth muscle cells and perivascular nerves on cerebral vessels (see Table 1). Electrical or pharmacological stimulation of cholinergic fibres on cerebral arteries can, depending on the species, the site of action, receptor subtype and concentration of ACh released, induce either Cited by: 6.

Pericytes, mural cells of microvascular capillaries, are regulators of vascular morphogenesis and pericytes is findings show how absence of Notchdependent input in perivascular cells - cerebral aneurysms. The first 72 hours after aneurysm rupture is a critical window during which the.

Getting a grip on cerebral blood flow Posted on Thursday, Octo by Mo Costandi under Molecular Cell Biology, Neuroscience The brain, an energy-hungry organ which consumes one-fifth of the body’s energy, controls its own blood supply, which is no mean feat.

Normal cells of the brain include neurons, glia, and microglia, as well as endothelial and perivascular cells, leptomeningeal cells, melanocytes, and choroid plexus. The morphologies, organization, and function of these cell types vary dramatically based on brain region, which is evident by the contrasting histologic features of the cerebral Cited by: 4.

The deep cerebral veins drain blood in a centripetal direction from the deep white matter, the basal ganglia, and the diencephalon toward the lateral ventricles. Large subependymal veins empty into the internal cerebral and basal veins, which unite and contribute to the formation of the great cerebral vein also known as the “vein of Galen.”.

Title: A Hyperlipidemic Diet Induces Structural Changes in Cerebral Blood Vessels VOLUME: 8 ISSUE: 2 Author(s):Elena Constantinescu, Florentina Safciuc and Anca V.

Sima Affiliation:Department of Cerebrovascular Dysfunctions, Institute of Cellular Biology and Pathology “N Simionescu”, 8, B.P.

Hasdeu StreetBucharest, Romania. A-connect different regions of the cerebral cortex with the opposite hemisphere. B-extend between the right and left cerebral hemispheres. C-link the cerebral cortex to the caudal brain regions and the spinal cord. D-connect different regions of the cerebral cortex within the same hemisphere.

E-None of the choices is correct. Cerebral endothelial cells, pericytes, and smooth muscle cells are the target of these signals and transduce them into coordinated vascular adjustments that ultimately lead to an increase in CBF. Therefore, the increase in flow evoked by brain activity is mediated by the concerted action of multiple mediators that originate from different cells Cited by: Start studying Chapter Disorders of brain function Porth Learn vocabulary, terms, and more with flashcards, games, and other study tools.

This chapter summarizes the current knowledge regarding the regulation of the tone of cerebral resistance arteries under conditions of normal health and with the development of chronic diseases (e.g., metabolic disease).

The work integrates the myogenic (pressure-induced) regulation of vascular tone, the impact of elevated luminal flow or shear stresses, that of local tissue metabolic activity. Perivascular cells stained with astrocyte specific glial fibrillary associated protein (GFAP) and general F-actin staining with Phalloidin demonstrated consistent morphology in the influx and Cited by: Primer on Cerebrovascular Diseases, Second Edition, is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain book consists of short, specific chapters written by international experts on cerebral vasculature, presenting the information in a.

Pages where the terms "Historic" (textbooks, papers, people, recommendations) appear on this site, and sections within pages where this disclaimer appears, indicate that the content and scientific understanding are specific to the time of means that while some scientific descriptions are still accurate, the terminology and interpretation of the developmental mechanisms reflect.

Transplanted cells were identified within newly formed perivascular walls as pericytes, a proportion of which were functional. Newly formed blood vessels were found within the cell sheet that had anastomosed to the cerebral blood vessels in the by: 3.

The brain is a heterogeneous organ with regionally varied and constantly changing energetic needs. Blood vessels in the brain are equipped Cited by: The estimation of the number or density of neurons and types of glial cells and their relative proportions in different brain areas are at the core of rigorous quantitative neuroanatomical studies.

Unfortunately, the lack of detailed, updated, systematic and well-illustrated descriptions of the cytology of neurons and glial cell types, especially in the primate brain, makes such studies Cited by: Human brain. The human brain is a component of the central nervous system.

The human brain is roughly the size of two clenched fists and weighs about kg ( lb) in men and kg in women 1).The difference between the sexes is proportional to body size, not intelligence.

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